Detoxifying compound and process of making it



UNITED STATES PATENT arms.

eos'mvn P. mn'ra or 3306mm NEW YORK, ASSIGNOR ro n. A. mn'rz LABORA- TORIES, IN Q, OF NEW YORK, mm, A coaroaa'rron or NEW YORK.

DETOXIFYING COMPOUND AND PROCESS Oi MAKING IT.

No Drawing.

, To all whom it may concern:

portions of Be it known that I, GUs'rAvE P. Mn'rz, a citizen of the United States, residin at Brooklyn, in the county of Kings and tate of New York, have invented certain new and useful Improvements in a 'Detoxifying Compound and Processes of Making It, of which the following isia specification.

Carbamid (urea) is known to form double salts or molecular compounds with various inorganic salts, notably with calcium nitrate, calcium bromide and calcium chloride. The salt or compound of calcium chloride and carbamid containing one molecule of calcium chloride and four moleclues of carbamid is a valuable aid in calcium therapy.

Sodium thiosulfate is extensively used in the treatment of arsenical dermatitis. It is reported to giv e good results in mercury and lead poisoning and recent medical literature shows it to possess high clinical value in metallic toxemias. I The mechanism of the action of sodium thiosulfate is not accurately known, but it probably consists in dislodg- The new compounds have ;-a,very low toxicity'and are capable of forming sterile stable solutions suitable for intravenous injection. They do not irritate the tissues or cause pain on injection.

One, two, three or four molecular procarbamid may be combined with one molecular proportion of-sodium 'thiosulfate. On account of its physical and therapeutic properties the'combination of one molecule of sodium thiosulfate with four Application filed Novembcr 6, 1925. Serial No. 67,435.

moleculesof carbamid is most suitable for clinical application.

Example I.124 gms. of crystallized sodium thiosulfate are mixed intimately with 120 gms. of 'carbamid (molecular ratio 1 :4). low dish on a steam bath or sand bath until asmooth 'melt is obtained. The temperature of the melt should not be allowed to run over 120 C. The heating is continued until about 3 m'ols. of the original 5 mols. of water of crystallization of the sodium thiosulfate have evaporated, and the net Weight of the mixture has been reduced to about 220 gms. After cooling, the crystal- The mixture is heated in a shalline cake is finely powdered, dried in air,

and sifted. The product is a white crystalline powder, stable when exposed to the air. It is readily and completely soluble in water. It contains about 37% active Na S O as determined titrimetrically and about 7% H O as water of crystallization.

This stable hydrate containing 7% H O is also obtainable by drying the melt in air after cooling and powdering, or by drying in vacuum,

Example H.--Following exactly the same procedure as in Example I, but using 124 7 guns. crystallized sodium thiosulfate and 90 )gms. carbamid (molecular pro 1-3 containing 43% active Na S O and '78% water of crystallization. 1

Example III.As an alternative-method rtion a whlte crystalline powder 18 o tained of preparation; the melt as obtained-in Examples I or cooling. The compound of carbamid and sodium thiosulfate se arates out in the form of white crystalline akes which are filtered oil by suction and dried in air or vacuum. The product obtained in this way contains about 48% Na S O and 3 to 4% H O.

In a similar manner, com ounds containing the car'bamid and the so ium'thiosulfate in the molecular ratios: of 2 :1 and lzl may be prepared and it"is of course obvious that l I II may bepoured into- 3 to 4 Volumes of 95% alcohol with stirring and molecular ratios intermediate the ratios represented by the whole numbers 1, 2, 3 and 4 may be employed.

I claim: 1. As a new product a compound of carbu- 6 mid and sodium thiosulfate.

2. As a new product a compound of carbaj mid and sodium thiosulfate, the molecular ratio of the carbamid to the sodium thiosulfate in said compound lying'within the range from 4:1 to 1 :1.

3. As a new product a compound of carbamid and sodium theiosulfate the molecular ratio of the carbamid to the sodium thiosul- 'fate in said compound being 4:1.

GUSTAVE P. METZ. 

